MTLD, a Database of Multiple Target Ligands, the Updated Version.

Creation of a free, Internet-accessible database: the Multiple Target Ligand Database

BACKGROUND Polypharmacology plays an important part in drug discovery, and remains a major challenge in drug development. Identification of the underlying polypharmacology of a drug, as well as development of polypharmacological drugs, have become important issues in the pharmaceutical industry and academia. DESCRIPTION Herein, through data mining of the Protein Data Bank (PDB), a free, Inter...

Multiple Target Laser Designator ( MTLD ) Quarterly Status Report # 6 Contract No . N 00014 - 05 - C - 0423

The Ligand Gated Ion Channel Database

The ligand gated ion channels (LGICs) are ionotropic receptors to neurotransmitters. Their physiological effect is carried out by the opening of an ionic channel upon binding of a particular neurotransmitter. These LGICs constitute superfamilies of receptors formed by homologous subunits. A database has been developed to handle the growing wealth of cloned subunits. This database contains nucle...

sRNATarBase 3.0: an updated database for sRNA-target interactions in bacteria

Bacterial sRNAs are a class of small regulatory RNAs of about 40-500 nt in length; they play multiple biological roles through binding to their target mRNAs or proteins. Therefore, elucidating sRNA targets is very important. However, only targets of a few sRNAs have been described. To facilitate sRNA functional studies such as developing sRNA target prediction models, we updated the sRNATarBase...

Recent Trends in the Management of Pulmonary Hypertension

Context. Pulmonary hypertension is a common clinical problem encountered in day-to-day practice. Drug therapy forms the backbone of management and appropriate drug selection is based upon the underlying causes. The options available are widening with availability of newer therapeutic agents and thus it becomes necessary to be updated with the recent developments. Objective. To review the existi...